| Date | Location | Result | |
| Dec 29, 2010 | Washington, DC | Maryland 51, East Carolina 20 | Box score |
| Nov 26, 2010 | Greenville, N.C. | SMU 45, East Carolina 38 | Box score |
| Nov 20, 2010 | Houston, Texas | Rice 62, East Carolina 38 | Box score |
| Nov 11, 2010 | Birmingham, Ala. | East Carolina 54, UAB 42 | Box score |
| Nov 06, 2010 | Greenville, N.C. | NAVY 76, East Carolina 35 | Box score |
| Oct 30, 2010 | Orlando, Fla. | UCF 49, East Carolina 35 | Box score |
| Oct 23, 2010 | Greenville, N.C. | East Carolina 37, Marshall 10 | Box score |
| Oct 16, 2010 | Greenville, N.C. | East Carolina 33, N.C. State 27 | Box score |
| Oct 09, 2010 | Hattiesburg, Miss. | East Carolina 44, Southern Miss 43 | Box score |
| Oct 02, 2010 | Chapel Hill, NC | North Carolina 42, East Carolina 17 | Box score |
| Sep 18, 2010 | Blacksburg, Va. | Virginia Tech 49, East Carolina 27 | Box score |
| Sep 11, 2010 | Greenville, N.C. | East Carolina 49, Memphis 27 | Box score |
| Sep 5, 2010 | Greenville, N.C. | East Carolina 51, Tulsa 49 | Box score |